Analysis of Serum Cytokine Levels in Larynx Squamous Cell Carcinoma and Dysplasia Patients

Authors

  • Cem Sezer Department of Pathology, Antalya Education and Research Hospital, Antalya, Turkey
  • Hulya Eyigor Department of ENT Head and Neck Surgery, Antalya Education and Research Hospital
  • Meral Gultekin Akdeniz University Medical Faculty, Department of Medical Microbiology
  • Mete Eyigor Akdeniz University Medical Faculty, Department of Medical Microbiology
  • MustafaDeniz Yilmaz Department of ENT Head and Neck Surgery, Antalya Education and Research Hospital
  • Nuray Erin Akdeniz University Medical Faculty, Department of Medical Pharmacology
  • Omer Tarik Selcuk Department of ENT Head and Neck Surgery, Antalya Education and Research Hospital
  • Sadi Koksoy Akdeniz University Medical Faculty, Department of Medical Microbiology
  • Ustun Osma Department of ENT Head and Neck Surgery, Antalya Education and Research Hospital
Abstract:

Background: Although the imbalance of cytokines in Head and Neck Squamous Cell Carcinoma (HNSCC) is well known, there is scarce data regarding its occurrence during dysplasia, before the malignant transformation. Objective: To determine whether laryngeal dysplasia patients show a different cytokine profile than patients with cancer and healthy controls. Methods: Seventeen newly diagnosed, untreated larynx squamous cell carcinoma (SCC) and six laryngeal dysplasia patients as well as 22 healthy controls were analyzed for circulating cytokines. A flowcytometry Th1/Th2 cytokine array kit was used to quantitatively measure Interleukin-2 (IL-2), IL-4, IL-6, IL-10, Tumor Necrosis Factor-α (TNF-α) and Interferon-γ (IFN-γ) levels. Additionally, IL-8 levels were determined through ELISA. Results: IL-6, IL-8 and IL-10 were determined to be statistically increased in SCC patients (p

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Journal title

volume 11  issue 4

pages  259- 268

publication date 2014-12-01

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